• 6th IFAD 2017

    FIRST BATCH OF EARLY BIRD ONLINE REGISTRATIONS NOW OPEN

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    November 23-25th 2017
    Hilton Congress Centre, Antwerp, Belgium

    We are very pleased to announce the Sixth International Fluid Academy Days, which will take place on November 23-25th 2017 at the Hilton Hotel in Antwerp, Belgium. The aim of this sixth edition is again to review recent advances in fluid management, and hemodynamic and organ function monitoring in the critical care setting in a comprehensive manner for intensivists, anaesthesiologists and emergency physicians as well as interested internists and surgeons. However the meeting will deal with any broad topic related to critical care. As always it is also a great way to promote professional interaction between faculty members, participants and delegates of the industry. This website is regularly updated. Last modification by Adminstrator (Manu Malbrain) on March 19th 2017 at 10:00 AM

  • About iFAD

    The iFAD started as local initiative form the pharmaceutical working group on fluids from the Ziekenhuis Netwerk Antwerpen (www.zna.be). Today iFAD is integrated within the not-for-profit charitable organization iMERiT, International Medical Education and Research Initiative, under Belgian law and as such the iFAD Organising Committee strongly recognizes and values a constructive partnership with the industry.

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  • Brand new website!

    The IFAD website content is based on the philosophy of FOAM (Free Open Access Medical education – #FOAMed). The organising committee gives their time freely and receives no financial benefit. This in part explains the wonderful passions for philanthropy, sharing, education and innovation that make the IFAD unique.

  • Free Open Access Medical Education and Member Benefits

    The International Fluid Academy adheres to the FOAM principles for all website visitors: FREE Open Access Medical Education (#FOAMed #FOAMcc #FOAMus).

    We are very pleased to announce the Sixth International Fluid Academy Days, which will take place on November 23-25th 2017 at the Hilton Hotel in Antwerp, Belgium. The aim of this sixth edition is again to review recent advances in fluid management, and hemodynamic and organ function monitoring in the critical care setting in a comprehensive manner for intensivists, anaesthesiologists and emergency physicians as well as interested internists and surgeons. However the meeting will deal with any broad topic related to critical care. As always it is also a great way to promote professional interaction between faculty members, participants and delegates of the industry.

    Read more

  • iFAD history

    The iFAD started as local initiative from the pharmaceutical working group on fluids from the Ziekenhuis Netwerk Antwerpen (www.zna.be). Today iFAD is integrated within the not-for-profit charitable organization iMERiT...

    Read more

Workshop on PK/PD

Workshop on PK/PD

Pharmacokinetics/Pharmacodynamics made easy at the bedside (Limited places during IFAD2017)

Date: November 23rd, 2017

Location: Hilton Congress Centre, Groenplaats, Antwerp, Belgium

Room: TBA

Program Chair: Prof Dr Jan J De Waele, University Hospital Ghent, Belgium

Duration: 120 min

Pax: 40

Price: 100 EUR

Comment: This workshop can only be booked when attending the IFAD2017 meeting on Nov 24-25, 2017, at Hilton Congress Centre, Groenplaats, Antwerp, Belgium

Background:
Antibiotics save lives and are essential for the practice of intensive care medicine. Adequate antibiotic treatment is closely related to outcome. However this is challenging in the critically ill, as their pharmacokinetic profile is markedly altered. Therefore, it is surprising that critical care physicians continue to rely on standard dosing regimens for every patient, regardless of the actual clinical situation. At present, therapeutic drug monitoring may be of help, but has major disadvantages, remains unavailable for most antibiotics and has produced mixed results. Antibiotic dosing regimens are usually based on data from healthy volunteers with normal physiology or non-critically ill patients. However, in critically ill hospitalized patients, pathophysiological changes may have profound effects on the primary determinants of the pharmacokinetics (PK) of hydrophilic antibiotics which are distributed to interstitial fluid and that are predominantly excreted via the kidneys (like β-lactams, aminoglycosides, glycopeptides). Extravascular volume expansion with fluid loading in the setting of capillary leak (poor source control) may alter their volume of distribution (Vd), while changes in renal function can significantly influence drug clearance (Cl). The β-lactams are the most commonly prescribed antibiotics in the critically ill. Since bacterial killing is considered time-dependent, the pharmacodynamic (PD) parameter of interest is the fraction of time that the free drug concentration exceeds a minimum inhibitory concentration (MIC tested in vitro) of the causative microorganism – the fT>MIC.

PKPD 1
Picture courtesy adamondemand


Learning objective:
This workshop will outline the basic pharmacokinetic and pharmacodynamic principles that underlie the need for individualized and personalized drug dosing.

Draft scientific program (20min presentation with 10min for discussion)

  1. PK/PD of antimicrobials in the ICU – Isabel Spriet, Leuven, Belgium
  2. The impact of extracorporeal therapies – Fabio Taccone, Brussels, Belgium
  3. Antibiotic therapeutic drug monitoring (TDM) – ready for prime time? – Jan De Waele, Ghent, Belgium
  4. How to integrate big data in antibiotic therapy – Paul Elbers, Amsterdam, The Netherlands

Suggested reading:

  • Right dose, right now: using big data to optimize antibiotic dosing in the critically ill. Paul W.G. Elbers, Armand Girbes, Manu LNG Malbrain, Rob Bosman. DOI: 10.5603/AIT.a2015.0061. Anaesthesiol Intensive Ther 2015;47(5):457-463.
  • A pilot study on pharmacokinetic/pharmacodynamic target attainment in critically ill patients receiving piperacillin/tazobactam. Jiřina Martínková, Manu L.N.G. Malbrain, Eduard Havel, Petr Šafránek, Jan Bezouška, Milan Kaška. DOI: 10.5603/AIT.a2015.0082. Anaesthesiol Intensive Ther 2016;48(1):23-28.

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